Malcolm in the Middle
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| Award | Year (↓) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| RATTY Award | 2000 | Best Writing in a Comedy Series | Winner | Linwood Boomer |
| Cadet Award | 2000 | Outstanding Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| RATTY Award | 2000 | Best Writing in a Comedy Series | Nominee | Michael Glouberman, Andrew Orenstein |
| RATTY Award | 2000 | Best Directing in a Comedy Series | Winner | Todd Holland |
| Online Television Academy Award | 2000 | Best Theme Music in a New Television Series | Nominee | John Flansburgh, John Linnell |
| Emmy Award | 2000 | Outstanding Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| Cadet Award | 2000 | Outstanding Guest Actress in a Comedy Series | Winner | Beatrice Arthur |
| Online Television Academy Award | 2000 | Best Title Sequence in a New Series | Nominee | |
| Cadet Award | 2000 | Outstanding Writing in a Comedy Series | Nominee | Linwood Boomer |
| RATTY Award | 2000 | Best New Series | Nominee | |
| Cadet Award | 2000 | Outstanding Directing in a Comedy Series | Nominee | Todd Holland |
| Cadet Award | 2000 | Outstanding Directing in a Comedy Series | Nominee | Ken Kwapis |
| Time Magazine's Best/Worst List | 2000 | Top Ten Best Television Shows (#2) | Winner | |
| RATTY Award | 2000 | Series with the Most Potential | Winner | |
| Petcabus Award | 2000 | Best Guest Actor or Actress in a Comedy or Drama Series | Nominee | Beatrice Arthur |
| Cadet Award | 2000 | Outstanding Editing | Nominee | |
| Emmy Award | 2000 | Outstanding Guest Actress in a Comedy Series | Nominee | Beatrice Arthur |
| BMI TV Music Award | 2000 | Winner | John Linnel; John Flansburgh | |
| Cadet Award | 2000 | Outstanding Main Title Design | Nominee | |
| Teen Choice Award | 2000 | Choice TV Actor | Nominee | Frankie Muniz |
| Cadet Award | 2000 | Outstanding Production Design | Nominee |
