Malcolm in the Middle
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| Award | Year (↓) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Online Television Academy Award | 2001 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| Online Television Academy Award | 2001 | Best Ensemble Cast in a Comedy Series | Nominee | |
| Emmy Award | 2001 | Outstanding Multi-Camera Sound Mixing for a Series or Special | Nominee | |
| Cadet Award | 2001 | Outstanding Lead Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| Cadet Award | 2001 | Outstanding Supporting Actor in a Comedy Series | Nominee | Justin Berfield |
| Emmy Award | 2001 | Outstanding Writing for a Comedy Series | Winner | Alex Reid |
| Cadet Award | 2001 | Outstanding Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| Young Artist Award | 2001 | Best Performance by a Leading Young Actor in a Television Comedy Series | Winner | Frankie Muniz |
| Online Television Academy Award | 2001 | Best Guest Actor in a Comedy Series | Nominee | Robert Loggia |
| Young Artist Award | 2001 | Best Performance by a Supporting Young Actor in a Television Comedy Series | Winner | Craig Lamar Traylor |
| Online Television Academy Award | 2001 | Best Guest Actress in a Comedy Series | Nominee | Cloris Leachman |
| TV Guide Award (televised) | 2001 | Favorite Breakout Star | Nominee | Frankie Muniz |
| RATTY Award | 2001 | Best Comedy Series | Winner | |
| Directors Guild Award | 2001 | Outstanding Directorial Achievement in Television Comedy Series | Nominee | Todd Holland |
| Young Artist Award | 2001 | Best Performance by a Young Performer Guest-Starring in a Television Comedy Series | Nominee | Ashley Turner |
| Young Artist Award | 2001 | Best Performance by a Young Actor (Ten or Under) in a Television Comedy or Drama Series | Nominee | Erik Per Sullivan |
| RATTY Award | 2001 | Best Lead Actor in a Comedy Series | Nominee | Frankie Muniz |
| Online Television Academy Award | 2001 | Best Direction in a Comedy Series | Nominee | |
| RATTY Award | 2001 | Best Lead Actress in a Comedy Series | Winner | Jane Kaczmarek |
| Young Artist Award | 2001 | Best Performance by a Young Ensemble in a Television Comedy or Drama Series | Nominee | |
| RATTY Award | 2001 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| Online Television Academy Award | 2001 | Best Writing in a Comedy Series | Nominee | |
| Cadet Award | 2001 | Outstanding Guest Actor in a Comedy Series | Winner | Robert Loggia |
| Family Television Award | 2001 | Television Comedy Series | Winner | |
| Cadet Award | 2001 | Outstanding Guest Actress in a Comedy Series | Winner | Cloris Leachman |
| Family Television Award | 2001 | Television Actress | Winner | Jane Kaczmarek |
| Golden Eddie Award | 2001 | Best Edited Half-Hour Television Series | Winner | Nancy Morrison |
| RATTY Award | 2001 | Best Writing in a Comedy Series | Nominee | Ian Busch |
| RATTY Award | 2001 | Best Writing in a Comedy Series | Winner | Dan Kopelman |
| NAACP Image Award | 2001 | Outstanding Youth Actor or Actress | Nominee | Craig Lamar Traylor |
| Cadet Award | 2001 | Outstanding Writing in a Comedy Series | Nominee | Ian Busch |
| Cadet Award | 2001 | Outstanding Directing in a Comedy Series | Nominee | Todd Holland |
| American Comedy Awards | 2001 | Funniest Lead Female Performer in a Television Series | Winner | Jane Kaczmarek |
| Future Classic Award | 2001 | Winner | ||
| RATTY Award | 2001 | Best Directing in a Comedy Series | Winner | Todd Holland |
| American Comedy Awards | 2001 | Funniest Guest Female Performer in a Television Series | Winner | Beatrice Arthur |
| RATTY Award | 2001 | Best Guest Actor in a Comedy Series | Winner | Robert Loggia |
| Kids Choice Award | 2001 | Favorite TV Show | Winner | |
| Peabody Award | 2001 | Winner | ||
| RATTY Award | 2001 | Best Ensemble in a Comedy Series | Winner | |
| Emmy Award | 2001 | Outstanding Directing for a Comedy Series | Winner | Todd Holland |
| Emmy Award | 2001 | Outstanding Directing for a Comedy Series | Nominee | Jeff Melman |
| Television Critics Association Award | 2001 | Outstanding Comedy Series | Winner | |
| Television Critics Association Award | 2001 | Outstanding Individual Achievement in a Comedy Series | Nominee | Bryan Cranston |
| Television Critics Association Award | 2001 | Outstanding Individual Achievement in a Comedy Series | Winner | Jane Kaczmarek |
| Teen Choice Award | 2001 | Choice TV Actor | Nominee | Frankie Muniz |
| Petcabus Award | 2001 | Best Comedy Series | Nominee | |
| Online Television Academy Award | 2001 | Best Episode in a Comedy Series | Winner | |
| Teen Choice Award | 2001 | Choice TV Sidekick | Nominee | Erik Per Sullivan |
| Viewers Voice Award | 2001 | Favorite Half-Hour Series | Nominee |
