Malcolm in the Middle
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| Award | Year (↑) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Teen Choice Award | 2000 | Choice TV Breakout Show | Nominee | |
| TeeVee Award | 2000 | Best Half-Hour Actress | Winner | Jane Kaczmarek |
| Emmy Award | 2000 | Outstanding Writing for a Comedy Series | Winner | Linwood Boomer |
| TeeVee Award | 2000 | Best Half-Hour Show | Winner | |
| RATTY Award | 2000 | Best Comedy Series | Winner | |
| Online Television Academy Award | 2000 | Best New Comedy Series | Winner | |
| Young Star Award | 2000 | Best Performance by a Young Actor in a Comedy Television Series | Winner | Frankie Muniz |
| RATTY Award | 2000 | Best Ensemble in a Comedy Series | Nominee | |
| Young Star Award | 2000 | Best Young Ensemble Cast in a Television Series | Winner | |
| Online Television Academy Award | 2000 | Best Lead Actor in a Comedy Series | Nominee | Frankie Muniz |
| Online Television Academy Award | 2000 | Best Lead Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| RATTY Award | 2000 | Best Lead Actor in a Comedy Series | Winner | Frankie Muniz |
| Emmy Award | 2000 | Outstanding Casting for a Comedy Series | Nominee | |
| Online Television Academy Award | 2000 | Best Actor in a New Comedy Series | Winner | Frankie Muniz |
| Online Television Academy Award | 2000 | Best Actress in a New Comedy Series | Winner | Jane Kaczmarek |
| Cadet Award | 2000 | Outstanding Comedy Series | Nominee | |
| RATTY Award | 2000 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| Petcabus Award | 2000 | Best Comedy Series | Nominee | |
| RATTY Award | 2000 | Best Supporting Actress in a Comedy Series | Winner | Jane Kaczmarek |
| Viewers for Quality Television Award | 2000 | Best Actress in a Quality Comedy Series | Nominee | Jane Kaczmarek |
| Cadet Award | 2000 | Outstanding Debut Series | Nominee | |
| Artios Award | 2000 | Best Casting for an Episodic Comedy Series | Nominee | Nikki Valko, Ken Miller |
| Television Critics Association Award | 2000 | Outstanding Comedy Series | Winner | |
| Online Television Academy Award | 2000 | Best Guest Actress in a Comedy Series | Winner | Beatrice Arthur |
| Artios Award | 2000 | Best Casting for a Comedy Pilot | Winner | Mary V. Buck, Susan Edelman |
| Emmy Award | 2000 | Outstanding Directing for a Comedy Series | Winner | Todd Holland |
| Television Critics Association Award | 2000 | Outstanding New Program of the Year | Nominee | |
| Petcabus Award | 2000 | Best Actor in a Comedy Series | Nominee | Frankie Muniz |
| Television Critics Association Award | 2000 | Outstanding Individual Achievement in a Comedy Series | Winner | Jane Kaczmarek |
| Television Critics Association Award | 2000 | Outstanding Individual Achievement in a Comedy Series | Nominee | Frankie Muniz |
| RATTY Award | 2000 | Best Guest Actor in a Comedy Series | Nominee | Craig Lamar Traylor |
| RATTY Award | 2000 | Best Guest Actress in a Comedy Series | Winner | Beatrice Arthur |
| Petcabus Award | 2000 | Best Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| Online Television Academy Award | 2000 | Best Writing in a Comedy Series | Nominee | |
| Cadet Award | 2000 | Outstanding Lead Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| Petcabus Award | 2000 | Best Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| RATTY Award | 2000 | Best Writing in a Comedy Series | Winner | Linwood Boomer |
| Cadet Award | 2000 | Outstanding Supporting Actor in a Comedy Series | Nominee | Bryan Cranston |
| RATTY Award | 2000 | Best Writing in a Comedy Series | Nominee | Michael Glouberman, Andrew Orenstein |
| RATTY Award | 2000 | Best Directing in a Comedy Series | Winner | Todd Holland |
| Online Television Academy Award | 2000 | Best Theme Music in a New Television Series | Nominee | John Flansburgh, John Linnell |
| Emmy Award | 2000 | Outstanding Actress in a Comedy Series | Nominee | Jane Kaczmarek |
| Cadet Award | 2000 | Outstanding Guest Actress in a Comedy Series | Winner | Beatrice Arthur |
| Online Television Academy Award | 2000 | Best Title Sequence in a New Series | Nominee | |
| Cadet Award | 2000 | Outstanding Writing in a Comedy Series | Nominee | Linwood Boomer |
| RATTY Award | 2000 | Best New Series | Nominee | |
| Cadet Award | 2000 | Outstanding Directing in a Comedy Series | Nominee | Todd Holland |
| Cadet Award | 2000 | Outstanding Directing in a Comedy Series | Nominee | Ken Kwapis |
| Time Magazine's Best/Worst List | 2000 | Top Ten Best Television Shows (#2) | Winner | |
| RATTY Award | 2000 | Series with the Most Potential | Winner |
