Prison Break
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| Award (↓) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Tubey Award | 2007 | The Best Way to Visit Europe Without Leaving Home or Flipping on the Travel Channel Award | Winner | |
| Tubey Award | 2006 | Show with the Most HoYay (#3) | Voted | |
| Time Magazine's Best/Worst List | 2005 | Top Ten Best Television Shows (#9) | Winner | |
| TelevisionWeek's Critics Poll | 2006.02 | Best Television (#19) | Winner | |
| TelevisionWeek's Critics Poll | 2006.01 | Best Television (#7) | Winner | |
| Television Critics Association Award | 2006 | Outstanding New Program of the Year | Nominee | |
| Teen Choice Award | 2008 | Choice TV Show - Action/Adventure | Nominee | |
| Teen Choice Award | 2008 | Choice TV Actor - Action/Adventure | Nominee | Wentworth Miller |
| Teen Choice Award | 2007 | Choice TV Actor - Drama | Nominee | Wentworth Miller |
| Teen Choice Award | 2007 | Choice TV Villain | Nominee | Robert Knepper |
| Teen Choice Award | 2006 | Choice TV Breakout Star | Nominee | Wentworth Miller |
| Teen Choice Award | 2006 | Choice TV Breakout Show | Nominee | |
| Teen Choice Award | 2006 | Choice TV Actor | Nominee | Wentworth Miller |
| Teen Choice Award | 2006 | Choice TV Sidekick | Nominee | Amaury Nolasco |
| Saturn Award | 2006 | Best Actor on Television | Nominee | Wentworth Miller |
| Saturn Award | 2006 | Best Network Television Series | Nominee | |
| RATTY Award | 2006 | Best New Series | Winner | |
| RATTY Award | 2006 | Best Lead Actor in a Drama Series | Nominee | Wentworth Miller |
| People's Choice Award | 2006 | Favorite New Television Drama Series | Winner | |
| People Magazine's Best/Worst List | 2005 | 10 Sizzling Shows | Winner | |
| Internet TV Award | 2006 | Favorite Actor in a Primetime Drama Series | Nominee | Wentworth Miller |
| Golden Tater Award | 2007 | Best Baddie (#3) | Voted | Robert Knepper |
| Golden Tater Award | 2007 | Best Kiss (#4) | Voted | Michael & Sara |
| Golden Tater Award | 2006 | Best Show of Skin (#2, tie) | Voted | Michael Scofield (Wentworth Miller) showing his blueprints |
| Golden Tater Award | 2006 | Favorite Drama King (#5) | Voted | Wentworth Miller |
| Golden Tater Award | 2006 | Breakout Star, Male (#1) | Voted | Wentworth Miller |
| Golden Tater Award | 2006 | Best New Show (#1) | Voted | |
| Golden Tater Award | 2006 | Best Baddie (#3) | Voted | T-Bag |
| Golden Tater Award | 2006 | Best Kiss (#5) | Voted | Michael (Wentworth Miller) & Sara (Sarah Wayne Callies) |
| Golden Tater Award | 2005 | Show You Look Forward to the Most (#1) | Voted | |
| Golden Satellite Award | 2006 | Best Supporting Actor in a Television Series, Miniseries or Motion Picture | Nominee | Robert Knepper |
| Golden Reel Award (MPSE) | 2007 | Outstanding Music Editing in Short Form Television | Nominee | |
| Golden Reel Award (MPSE) | 2007 | Outstanding Sound Editing in Short Form Television - Sound Effects and Foley | Nominee | |
| Golden Globe Award | 2006 | Outstanding Television Drama Series | Nominee | |
| Golden Globe Award | 2006 | Outstanding Actor in a Television Drama Series | Nominee | Wentworth Miller |
| Golden Gasm Award | 2006 | Most Shocking Moment | Nominee | Various toes, eyeballs, penises, and hands chopped, cut, or gouged out |
| Golden Gasm Award | 2006 | Best New Series, Scripted | Winner | |
| Golden Gasm Award | 2006 | Best Villain, Scripted | Nominee | Teabag |
| Golden Gasm Award | 2006 | Best Villain, Scripted | Nominee | Officer Bellick |
| Golden Eddie Award | 2006 | Best Edited One Hour Television Series for Commercial Television | Nominee | Mark Helfrich |
| futoncritic's Best Eps | 2006 | 50 Best Eps of 2005 (#25) | Winner | |
| futoncritic's Best Eps | 2006 | 50 Best Eps of 2005 (#24) | Winner | |
| Entertainment Weekly's Best/Worst List | 2005 | The Ten Best (#10) | Winner | |
| Empire | 2008 | 50 Greatest TV Shows of All Time (#49) | Winner | |
| Emmy Award | 2006 | Outstanding Main Title Theme Music | Nominee | Ramin Djawadi |
| Cult TV Award | 2007 | Best Returning Terrestrial Series | Nominee | |
| Cult TV Award | 2006 | Best New Terrestrial Series | Nominee | |
| Cult TV Award | 2006 | Breakthrough Performance | Nominee | Wentworth Miller |
| Cadet Award | 2006 | Outstanding Sound Editing | Nominee | |
| Cadet Award | 2006 | Outstanding Main Theme Music | Nominee |
