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| Award | Year (↑) | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| Bravo's All Time Greatest/Worst Lists | 2004 | 100 Greatest TV Characters (#95) | Winner | George Clooney |
| Online Television Academy Award | 2004 | Best Guest Actor in a Drama Series | Nominee | Don Cheadle |
| Online Television Academy Award | 2004 | Best Guest Actor in a Drama Series | Winner | Bob Newhart |
| Tubey Award | 2004 | Most Ludicrous Plotline (#1) | Voted | Romano vs. Helicopter |
| Tubey Award | 2004 | Biggest WTF Moment (#1) | Voted | Romano vs. Helicopter |
| Teen Choice Award | 2004 | Choice TV Breakout Female Star | Nominee | Parminder Nagra |
| SHINE Award | 2004 | Drama Episode | Nominee | |
| Tubey Award | 2004 | Becker Award: Show That Has Millions of Viewers, But No One Knows Anyone Who Watches It On Purpose | Winner | |
| NAACP Image Award | 2004 | Outstanding Supporting Actor in a Drama Series | Winner | Mekhi Phifer |
| PRISM Award | 2005 | Outstanding Television Drama Series Multi-Episode Storyline | Winner | |
| Online Television Academy Award | 2005 | Best Guest Actor in a Drama Series | Winner | Bob Newhart |
| ASCAP Film & TV Music Award | 2005 | Top Television Series | Winner | James Newton Howard |
| Young Artist Award | 2005 | Best Performance by a Recurring Young Actor in a Television Comedy or Drama Series | Nominee | Oliver Davis |
| TV Guide's All Time Greatest/Worst Lists | 2005 | 20 Hottest TV Kisses (#14) | Winner | Carol & Doug |
| NAACP Image Award | 2005 | Outstanding Drama Series | Nominee | |
| Young Artist Award | 2005 | Best Performance by a Young Actor Guest-Starring in a Television Comedy or Drama Series | Nominee | Cody Estes |
| Young Artist Award | 2005 | Best Performance by a Young Actress (Ten or Under) in a Television Comedy or Drama Series | Nominee | Kali Majors |
| NAACP Image Award | 2005 | Outstanding Supporting Actor in a Drama Series | Winner | Mekhi Phifer |
| Humanitas Prize | 2005 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Dee Johnson |
| Golden Tater Award | 2005 | Star You'll Miss the Most (#4) | Voted | Noah Wyle |
| Emmy Award | 2005 | Outstanding Stunt Coordination | Nominee | Cort L. Hessler III |
| Emmy Award | 2005 | Outstanding Guest Actor in a Drama Series | Nominee | Red Buttons |
| Emmy Award | 2005 | Outstanding Guest Actor in a Drama Series | Winner | Ray Liotta |
| Online Television Academy Award | 2005 | Best Supporting Actress in a Drama Series | Nominee | Parminder Nagra |
| RATTY Award | 2005 | Best Guest Actress in a Comedy Series | Nominee | Julianna Margulies |
| Directors Guild Award | 2005 | Outstanding Directorial Achievement in Television Drama Series | Nominee | Christopher Chulack |
| PRISM Award | 2005 | Outstanding Television Drama Series Episode | Winner | |
| Amy Award | 2005 | Beating a Dead Horse (a.k.a. Why Does TV Gal Still Talk About This Show?) | Nominee | |
| Voice Award | 2005 | Television | Winner | |
| Gabriel Award | 2005 | Entertainment/Arts: National Release | Winner | |
| PRISM Award | 2005 | Outstanding Performance in a Television Drama Series Episode | Winner | Ray Liotta |
| BMI TV Music Award | 2005 | Winner | Martin Davich | |
| TV Guide's All Time Greatest/Worst Lists | 2005 | 100 Most Unexpected TV Moments (#12) | Winner | Dr. Romano vs. the Helicopter |
| Golden Reel Award (MPSE) | 2006 | Outstanding Sound Editing in Short Form Television - Dialogue and Automated Dialogue Replacement | Nominee | |
| Golden Reel Award (MPSE) | 2006 | Outstanding Sound Editing in Short Form Television - Sound Effects and Foley | Winner | |
| Imagen Award | 2006 | Best Primetime Television Series | Nominee | |
| NAACP Image Award | 2006 | Outstanding Supporting Actor in a Drama Series | Nominee | Mekhi Phifer |
| Humanitas Prize | 2006 | 60 Minute Primetime Network, Syndicated, Cable or PBS Teleplay | Finalist | Janine Sherman Barrois |
| Asian Excellence Award | 2006 | Outstanding Female TV Performance | Nominee | Parminder Nagra |
| ASCAP Film & TV Music Award | 2006 | Top Television Series | Winner | James Newton Howard |
| BMI TV Music Award | 2006 | Winner | Martin Davich | |
| Emmy Award | 2006 | Outstanding Sound Editing for a Series | Nominee | Walter Newman, Tom Harris, Darleen Stoker, Rick M. Hromadka, Darren Wright, Kenneth Young, Bruce Honda, Sharyn Tylk-Gersh, Casey & Mike Crabtree |
| TV Land Award | 2006 | Most Memorable Kiss | Nominee | Dr. Doug Ross & Nurse Carol Hathaway |
| Emmy Award | 2006 | Outstanding Guest Actor in a Drama Series | Nominee | James Woods |
| Amy Award | 2007 | How Come It's Not YOU That's Dead? (Worst Character) | Nominee | Tony Gates |
| Emmy Award | 2007 | Outstanding Stunt Coordination | Nominee | Gary Hymes |
| Emmy Award | 2007 | Outstanding Guest Actor in a Drama Series | Nominee | Forest Whitaker |
| BMI TV Music Award | 2007 | Winner | Martin Davich | |
| Golden Reel Award (MPSE) | 2007 | Outstanding Sound Editing in Short Form Television - Dialogue and Automated Dialogue Replacement | Nominee | |
| Asian Excellence Award | 2007 | Outstanding Actress in Television | Winner | Parminder Nagra |
