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| Award (↑) | Year | Category | Nominee / Winner | Person |
|---|---|---|---|---|
| RATTY Award | 2006 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| RATTY Award | 2006 | Best Lead Actress in a Comedy Series | Nominee | Sarah Chalke |
| RATTY Award | 2005 | Most Improved Series | Nominee | |
| RATTY Award | 2005 | Best Comedy Series | Nominee | |
| RATTY Award | 2005 | Best Directing in a Comedy Series | Nominee | Adam Bernstein |
| RATTY Award | 2005 | Best Guest Actor in a Comedy Series | Nominee | Tom Cavanagh |
| RATTY Award | 2005 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| RATTY Award | 2004 | Best Supporting Actor in a Comedy Series | Winner | John C. McGinley |
| RATTY Award | 2004 | Best Guest Actor in a Comedy Series | Nominee | Brendan Fraser |
| RATTY Award | 2004 | Best Writing in a Comedy Series | Winner | Neil Goldman; Garrett Donovan |
| RATTY Award | 2004 | Best Directing in a Comedy Series | Nominee | Chris Koch |
| RATTY Award | 2003 | Best Comedy Series | Winner | |
| RATTY Award | 2003 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| RATTY Award | 2003 | Best Supporting Actor in a Comedy Series | Winner | John C. McGinley |
| RATTY Award | 2003 | Best Supporting Actress in a Comedy Series | Nominee | Sarah Chalke |
| RATTY Award | 2003 | Best Supporting Actress in a Comedy Series | Nominee | Judy Reyes |
| RATTY Award | 2002 | Best New Series | Nominee | |
| RATTY Award | 2002 | Best Comedy Series | Winner | |
| RATTY Award | 2002 | Best Lead Actor in a Comedy Series | Nominee | Zach Braff |
| RATTY Award | 2002 | Best Supporting Actor in a Comedy Series | Winner | John C. McGinley |
| RATTY Award | 2002 | Best Writing in a Comedy Series | Winner | Bill Lawrence |
| RATTY Award | 2002 | Best Directing in a Comedy Series | Winner | Adam Bernstein |
| RATTY Award | 2002 | Best Guest Actor in a Comedy Series | Nominee | Brendan Fraser |
| Spirit Award | 2003 | in Media | Winner | |
| Teen Choice Award | 2007 | Choice TV Sidekick | Nominee | Donald Faison |
| Teen Choice Award | 2006 | Choice TV Sidekick | Nominee | Donald Faison |
| Teen Choice Award | 2006 | Choice TV Actor - Comedy | Nominee | Zach Braff |
| Teen Choice Award | 2005 | Choice TV Actor in a Comedy Series | Nominee | Zach Braff |
| Teen Choice Award | 2005 | Choice TV Comedy Series | Nominee | |
| Teen Choice Award | 2005 | Choice TV Sidekick | Nominee | Donald Faison |
| Teen Choice Award | 2004 | Choice TV Actor in a Comedy Series | Nominee | Zach Braff |
| Teen Choice Award | 2004 | Choice TV Sidekick | Nominee | Donald Faison |
| Teen Choice Award | 2004 | Choice TV Comedy Series | Nominee | |
| Teen Choice Award | 2003 | Choice TV Actor in a Comedy Series | Nominee | Zach Braff |
| Teen Choice Award | 2003 | Choice TV Actress in a Comedy Series | Nominee | Sarah Chalke |
| Teen Choice Award | 2003 | Choice TV Comedy Series | Nominee | |
| Teen Choice Award | 2002 | Choice TV Actor in a Comedy Series | Nominee | Zach Braff |
| Teen Choice Award | 2002 | Choice TV Comedy Series | Nominee | |
| TeeVee Award | 2005 | Best Half-Hour Actor | Winner | Donald Faison |
| TeeVee Award | 2003 | Best Half-Hour Actress | Winner | Sarah Chalke |
| TeeVee Award | 2003 | Best Half-Hour Show | Winner | |
| TeeVee Award | 2002 | Best Half-Hour Show | Winner | |
| TeeVee Award | 2002 | Best Half-Hour Actor | Winner | John C. McGinley |
| Television Critics Association Award | 2006 | Outstanding Achievement in a Comedy Series | Nominee | |
| Television Critics Association Award | 2002 | Outstanding Achievement in a Comedy Series | Nominee | |
| Television Critics Association Award | 2002 | Outstanding Individual Achievement in a Comedy Series | Nominee | John C. McGinley |
| TelevisionWeek's Critics Poll | 2006.02 | Best Television (#13) | Winner | |
| TelevisionWeek's Critics Poll | 2005.01 | Best Television (#17) | Winner | |
| TelevisionWeek's Critics Poll | 2004.01 | Best Television (#12) | Winner | |
| Tubey Award | 2007 | Best HoYay! Moment (#2) | Voted | Guy Love song |
